Proposal of a new procedure for the exploration of hepatocellular function. the trimethoxybenzene test (TMB)
Rousselet, F.; Fredj, G.; Clenet, M.
Annales de Biologie Clinique 34(5): 323-328
1976
ISSN/ISBN: 0003-3898 PMID: 1015669 Document Number: 100709
The authors propose a new method of exploration of liver cell function based on the study of demethylation of a rapidly assimilated atoxic compound, trimethoxybenzene (TMB) in dimethoxy-hydroxybenzene (DMHB). Whereas in normal subjects, the urinary excretion of the metabolites was rapid and marked, 180 mg within 3 hours after taking a 400 mg dose, in patients with liver cell failure, the excretion of DMHB was considerably reduced, 80 to 95% in cirrhosis.
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