Granisetron-dexamethasone combination for multiple day cisplatin
Pronzato, P.; Losardo, P.L.; Vaira, F.; Vigani, A.; Landucci, M.; Ghio, E.
Anticancer Research 15(5b): 2261-2263
1995
ISSN/ISBN: 0250-7005 PMID: 8572634 Document Number: 1006
Thirty-four, patients being given polychemotherapy schedules including cisplatin at the dose of 20 mg/sm for 5 days entered an antiemetic protocol with granisetron and dexamethasone at the doses of 3 mg and 8 mg respectively, both administered i.v. before cisplatin. A complete response (no episodes of vomiting) and a major response (< or = 2 episodes of vomiting) were observed in 14 and 12 patients respectively; the toxicity of the antiemetics was mild. It is concluded that the granisetron dexamethasone combination is able to achieve a high rate of antiemetic control in the special set of multiple day cisplatin treated patients.
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