The immunobiological role of alloantigens of host tissue compatibility in the structure of oncornaviruses

Klepikov, N.N.; Khagundokova, L.B.

Voprosy Virusologii 4: 449-453

1976


ISSN/ISBN: 0507-4088
PMID: 1007221
Document Number: 100502
H-2 antigens of mouse cells were shown to be incorporated into the Rauscher virus virion structure. Alloantibody to these antigens neutralized the infectious activity of the virus. Active immunization of mice with H-2 alloantigens reduces susceptibility of the animals to the virus. The experimental results suggest that alloantigens of host tissue compatibility incorporated into the virion membrane determine important immuno-biological properties of Rauscher virus.

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