Top Abstract Purchase Related
Home
>
Node
>
Subnode

Adjuvant regulation of T cell function

Reinisch, C.L.; Gleiner, N.A.; Schlossman, S.F.

Journal of Immunology 116(3): 710-715

1976

ISSN/ISBN: 0022-1767
PMID: 1082892
Document Number: 100246
The effect of complete Freund's adjuvant (CFA) on distinct T cell functions was investigated. Adjuvant was found to suppress the generation of cytolytic T cells in vivo when mixed with allogeneic P815 cells before immunization of C57BL/6 mice. Inoculation of the mice with either adjuvant or adjuvant emulsified with allogeneic cells resulted in whole splenic populations or immunoabsorbent-purified T cells that did not generate cytolytic activity in vitro against allogeneic cells. Mixing T cells from normal and adjuvant-treated mice before in vitro sensitization resulted in suppression of lytic activity. However, memory T cells were not subject to the same suppressive regulation as were precytotoxic T cells since adjuvant had no effect on subsequent boosting of memory.

Document emailed within 1 workday
Secure & encrypted payments

Kourounakis, L.; Kapusta, M.A. 1976: Restoration of diminished T-cell function in adjuvant induced disease by methotrexate: evidence for two populations of splenic T-cell suppressors Journal of Rheumatology 3(4): 346-354
Csaba, G. 1973: Regulation of cell function Orvosi Hetilap 114(5): 245-254
Yamaguchi, M.; Fukuyama, Y.; Ichinose, Y. 2003: Current status of the neo-adjuvant and adjuvant therapy for the resectable non-small cell lung cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 30(2): 203-208
Fleischer, B.; Schrezenmeier, H.; Wagner, H. 1986: Function of the CD4 and CD8 molecules on human cytotoxic T lymphocytes: regulation of T cell triggering Journal of Immunology 136(5): 1625-1628
Pries, R.; Wulff, S.; Kesselring, R.; Börngen, K.; Xie, L.; Wollenberg, B. 2008: Up-regulation of NK cell function against head and neck cancer in response to ss-isRNA requires TLR7 International Journal of Oncology 33(5): 993-1000
Kamesaki, H.; Zwiebel, J.A.; Reed, J.C.; Cossman, J. 1994: Role of bcl-2 and IL-5 in the regulation of anti-IgM-induced growth arrest and apoptosis in immature B cell lines. A cooperative regulation model for B cell clonal deletion Journal of Immunology 152(7): 3294-3305
Salazar-Onfray, F.; Charo, J.; Petersson, M.; Freland, S.; Noffz, G.; Qin, Z.; Blankenstein, T.; Ljunggren, H.G.; Kiessling, R. 1997: Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10 Journal of Immunology 159(7): 3195-3202
Repmann, R.üd.; Goldschmidt, A.J.W.; Richter, A. 2003: Adjuvant therapy of renal cell carcinoma patients with an autologous tumor cell lysate vaccine: a 5-year follow-up analysis Anticancer Research 23(2a): 969-974
Schmidtke, J.R.; Johnson, A.G. 1971: Regulation of the immune system by synthetic polynucleotides. I. Characteristics of adjuvant action on antibody synthesis Journal of Immunology 106(5): 1191-1200
Corvò, R.; Margarino, G.; Sanguineti, G.; Geido, E.; Scala, M.; Mereu, P.; Cavallari, M.; Bonanno, S.; Garaventa, G.; Barbieri, M.; Giaretti, W. 2000: Cell kinetics analysis in patients affected by squamous cell carcinoma of the head and neck treated with primary surgery and adjuvant radiotherapy Tumori 86(1): 53-58
Awaya, A.; Shioiri-Nakano, K. 1977: The effects of basic pancreatic trypsin inhibitor (BPTI) incorporated in Freund's complete adjuvant and in Freund's incomplete adjuvant containing Bordetella pertussis organisms (Per). Suppressive effect on cell mediated response to purified protein derivative and competing effect on antibody formation to Per in guinea pigs Japanese Journal of Experimental Medicine 47(5): 403-411
Dos Reis, G.A.; Shevach, E.M. 1982: Effect of cyclosporin a on T cell function in vitro: the mechanism of suppression of T cell proliferation depends on the nature of the T cell stimulus as well as the differentiation state of the responding T cell Journal of Immunology 129(6): 2360-2367
Adissu, H.A.; Schuller, H.M. 2004: Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: Implications for chemoprevention International Journal of Oncology 24(6): 1467-1472
GOtz, V.H. 1975: Experimental studies on the question of an adjuvant function of bromhexine Arzneimittel-Forschung 25(4): 607-615
Müller, H. 1990: Effects of adjuvant chemotherapy of breast cancer on gonadal function Zentralblatt für Gynakologie 112(13): 795-801
Wang, W.-Z.; Guo, X.; Chen, J.-C.; Yuan, P.-W.; Liu, Y.-H.; Li, Y.-M. 2007: Effect of Xianlong granules on immunological function in rats of adjuvant arthritis Zhongguo Zhong Yao Za Zhi 32(9): 846-849
Mongini, P.K.; Longo, D.L.; Paul, W.E. 1984: T cell regulation of immunoglobulin class expression in the B cell response to TNP-Ficoll: characterization of the T cell responsible for preferential enhancement of the IgG2a response Journal of Immunology 132(4): 1647-1653
Rose, D.P.; Davis, T.E. 1980: Effects of adjuvant chemohormonal therapy on the ovarian and adrenal function of breast cancer patients Cancer Research 40(11): 4043-4047
Kurabe, N.; Arai, S.; Miyazaki, T. 2009: Cell cycle and cell sizing regulation via death effector domain Seikagaku. Journal of Japanese Biochemical Society 81(1): 24-27
De Vellis, J.; McGinnis, J.F.; Cole, R. 1987: Selective effects of lead on the hormonal regulation of glial cell differentiation in cell culture Progress in Clinical and Biological Research 253: 217-227