Pharmacological alteration of the antigenic properties of experimental leukemias detected by lymphocyte transformation
Testorelli, C.; Missiroli, A.; Di Padova, F.; Nicolin, A.
Bollettino dell'Istituto Sieroterapico Milanese 55(2): 142-150
1976
ISSN/ISBN: 0021-2547 PMID: 1023882 Document Number: 100004
It has previously been demonstrated that an in vitro antineoplastic treatment may induce new antigenic specificities in murine lymphomas. L1210 leukemia has been altered by DIC (L1210/DIC); drug-treated L1210 subline has been rejected by syngeneic animals. Here spleen cells from mice, normal or immune to L1210/DIC, have been stimulated in vitro by the L1210/DIC cells as measured by 3-h-thymidine uptake. Spleen cell stimulation did not occur with other syngeneic tumor cells and, as expected, spleen cells have been triggered by allogeneic cells. DIC-induced antigens stimulating syngeneic lymphocytes, as allogeneic cells did, have been demonstrated on L1210/DIC cells.