Spironolactone and acute mountain sickness
Currie, T.T.; Carter, P.H.; Champion, W.L.; Fong, G.; Francis, J.K.; McDonald, I.H.; Newing, R.K.; Nunn, I.N.; Sisson, R.N.; Sussex, M.; Zacharin, R.F.
Medical Journal of Australia 2(5): 168-170
1976
ISSN/ISBN: 0025-729X PMID: 979834 Document Number: 98897
Thirteen adults trekking in Nepal in 1974 to altitudes between 4,300 m and 5,500 m remained free from acute mountain sickness while taking spironolactone as a prophylactic measure. Two years previously five of these adults trekking at similar altitudes, but without treatment, had suffered from acute mountain sickness. The regime used was spironolactone in a dosage of 25 mg three times a day for two days preceding and during the periods spent at altitudes above 3,000 m.