General anesthesia with methoxyflurane given intravenously to the dog
Hilwig, R.W.
American Journal of Veterinary Research 37(3): 257-262
1976
ISSN/ISBN: 0002-9645 PMID: 1259220 Document Number: 98406
Dogs were anesthetized with liquid methoxyflurane administered intravenously by gaseous diffusion through sealed medical grade silicone rubber tubing placed in the femoral vein. A similar catheter placed in the other femoral vein and connected to a pressure transducer measured the increase in intraluminal pressure due to methoxyflurane diffusion into the 2nd catheter from the bloodstream 20 seconds after the catheter was flushed with room air. These pressures were plotted against venous blood methoxyflurane concentration, as determined by gas chromatography, for increasing lengths of anesthetic-administering catheter exposed to the bloodstream.