Free description of drug effects and description by questionaire of a sleep inducer (flurazepam) by normal test subjects
Kohnen, R.; Lienert, G.A.
Arzneimittel-Forschung 26(6): 1133-1136
1976
ISSN/ISBN: 0004-4172 PMID: 9110 Document Number: 97966
Giving flurazepam and placebo to students as subjects, the free description of drug-effects (FD) was compared to the description by a questionaire (QD). The results were: 1. The FD-method was more informative than the QD-method. 2. The FD-method induced less frequent placebo effects and more frequent verum-non-effects than did the QD-method. 3. The results (1) and (2) based mainly on the variables time-to fall-asleep, subjective quality of sleep and total time of sleep, in which variables flurazepam differed significantly from placebo.