Possible mode of action of nitroglycerin on heart mitochondria
Szekeres, L.; Vághy, P.; Bor, P.; Csete, K.
Recent Advances in Studies on Cardiac Structure and Metabolism 11: 495-500
1976
ISSN/ISBN: 0363-5872 PMID: 829646 Document Number: 97853
Nitroglycerin has no effect on the electron transport and oxidative phosphorylation of isolated rabbit heart mitochondria at 5 X 10(-4) M and lower concentrations. However, it diminished the phosphate-induced energy-dependent potassium fluxes through the mitochondrial membrane in both directions; thus it was able to prevent the impairment of the efficiency of oxidative phosphorylation produced by increased ion transport.