The pharmacokinetic profile of pentachlorophenol in monkeys
Braun, W.H.; Sauerhoff, M.W.
Toxicology and Applied Pharmacology 38(3): 525-533
1976
ISSN/ISBN: 0041-008X PMID: 827823 Document Number: 97536
Pentachlorophenol (PCP) is a registered antimicrobial agent used widely for the preservation of wood. The pharmacokinetic profile of PCP was defined in Rhesus monkeys [Macaca mulatta]. Three male and 3 female monkeys were given a single oral dose of 10 mg/kg [14C]PCP in corn oil. Concentrations of PCP were determined in plasma and urine at selected time intervals through 360 h post-administration. There were apparent sex-related differences in the 1st order clearance of PCP from plasma and excretion in urine. The half-life value for clearance of PCP from plasma was 83.5 h for females and 72.0 h for males while the half-life value for excretion was 92.4 and 40.8 h for females and males, respectively. Essentially all of the 14C activity excreted in urine was PCP. Biliary excretion and enterohepatic circulation were the probable explanations for the long half-life of PCP in the body of monkeys.