Radiation induced dysplasias of bone
Rubin, P.; Andrews, J.R.; Swarm, R.; Gump, H.
American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine 82(2): 206-216
1959
ISSN/ISBN: 0002-9580 PMID: 13670323 Document Number: 9739
1. Various forms of selective irradiation have been employed to induce modifications in cartilage growth, chondroclasis, osteogenesis and bone absorption. 2. Bone seeking isotopes in large doses produce zones of underconstriction in the metaphysis due to a failure in the absorptive processes, i.e., osteoclastic activity and marrow invasion via capillary growth. 3. Cartilage seeking isotopes in large doses arrest chondrogenesis and endochondral bone formation resulting in achondroplastic type bones. 4. Segmental external irradiation produces a variety of errors in bone modeling, depending upon the physiologic process altered. 5. Epiphyseal irradiated bones (Zones 1, 2 and 3) exhibit an arrest in chondrogenesis primarily; the metaphyseal irradiated group (Zones 4 and 5) shows a failure in the absorptive processes of calcified cartilage and bone; and the diaphvseal irradiated animals reflect alterations in periosteal activity.
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