Toxicity of benzhydrylurea under experimental conditions
Pashinskiĭ, V.G.; Aref'eva, A.K.; Sedova, K.S.; Motovilova, V.G.; Fil'tsanova, G.A.
Farmakologiia i Toksikologiia 39(3): 355-358
1976
ISSN/ISBN: 0014-8318 PMID: 1088365 Document Number: 97103
Benzhydrylurea, which displays an anticonvulsant action and is of low acute toxicity in capable after a 3-month administration to rats to inhibit the growth of male-rats, intensify the excretion of protein with the urine, raise the blood sugar level (with its single administration--to reduce), provoke dystrophic changes in the liver, kidneys and central nervous system. Following a 1--3-week introduction of the substance guinea pigs and cats demonstrate hemorrhagic erosions in the stomach and small intestine (but not rabbits, dogs and rats), the appearance of pathological forms of erythrocytes, while guinea pigs suffer from leucopoietic disorders.