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Change in the mitotic activity of hepatocytes and resorption of necrotic areas in the formation of liver cirrhosis

Petrovichev, N.N.

Biulleten' Eksperimental'noi Biologii i Meditsiny 81(5): 617-618

1976

ISSN/ISBN: 0365-9615
PMID: 181102
Document Number: 97062
Cirrhosis of the liver was induced in rats weighing 120--140 g by CCl4 administration for a period of 2 months. Iodated oil, which caused emboly of the portal vein branches and foci of necrosis in the heptic tissue, was administered through the spleen to experimental and intact animals. The volume of necrotic foci, and also the mitotic actinity of hepatites were determined. Necrotic foci resolved more rapidly in cirrhosis of the liver. An increase of mitotic index of the second day after the administration of iodated oil was more significant in control rats.

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