Oral contraceptives with lower hormonal dosis
Nesheim, B.I.
Tidsskrift for den Norske Laegeforening Tidsskrift for Praktisk Medicin Ny Raekke 96(23): 1219
1976
ISSN/ISBN: 0029-2001 PMID: 968845 Document Number: 96863
A new combination preparation, Microgynon, consists of .15 mg D'L-norgestrel and .03 mg ethinyl estradiol. This dosage of estrogen is much lower than the .05 mg maximum set on combination preparations in Norway. Microgynon has a Pearl index of .12-.34 pregnancies/100 woman-years. Low estrogen dosage causes more spotting and breakthrough bleeding (1-3%), but should decrease toehr side effects markedly, especially thromboembolic disorders.
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