Immunodiagnosis of a metastasis in a patient with a history of double malignant disease
Gardner, M.A.; Maluish, A.; Halliday, W.J.; Clunie, G.J.
Medical Journal of Australia 1(14): 446-448
1975
ISSN/ISBN: 0025-729X PMID: 1160704 Document Number: 95965
This paper discusses the use made of the antigenic specificity of malignant tumours in the diagnosis and subsequent management of a patient with secondary malignant disease who had previously been treated for both carcinoma of the breast and malignant melanoma. A comparatively simple, rapid test (leucocyte adherence inhibition) was used to determine the patient's antitumour immunoreactivity. Cell-mediated immunity against both types of tumour was detected, but this was accompanied by serum-blocking factor corresponding to melanoma only, which indicated that the secondary malignant disease was melanoma.