Top Abstract Purchase Preview Related
Home
>
Node
>
Subnode

Permeability of human skin to selected anions and cations--in vitro studies

Laudańska, H.; Lemancewicz, A.; Kretowska, M.łg.; Reduta, T.; Laudański, T.

Research Communications in Molecular Pathology and Pharmacology 112(1-4): 16-26

2002

ISSN/ISBN: 1078-0297
PMID: 15080493
Document Number: 9590
Among the many factors influencing the human body every day, metal cations and anions are some of the most important and are constantly present in atmospheric fallout. Some of them such as sulfate or nitrate anions along with different detergents may cause pathological changes within the skin. The aim of this study was to estimate whether sulfate (SO4(2-)) and nitrate anions (NO3-) as well as metal cations, magnesium (Mg2+) and calcium (Ca2+) are able to pass through isolated patches of human skin and to investigate the dynamics of ion diffusion. Concentrations of the substances corresponded to those observed in the atmospheric fallout in two regions of Poland with low (Białowieza) and high (Katowice) pollution rate. Ion chromatography method was used to determine cations and anions levels. In vitro, we found human skin to be permeable to magnesium and calcium ions as well as sulfate and nitrate anions at concentrations observed in the atmospheric fallout in two regions of Poland having different levels of pollution. Diverse influence of sodium lauryl sulfate (SLS) detergent on the grade of metal ion permeability (acceleration in the first 10 hours of experiment) and anion permeability (lack of SO4(2-) influence) suggest the presence of different routes of ions penetration through the skin. It is also supported by different transportation characteristics of individual ions through the skin over time.

Document emailed within 1 workday
Secure & encrypted payments

Permeability of human skin to selected anions and cations--in vitro studies

Golutvina, M.M.; Semochkina, L.S. 1972: Effect of cations and anions on Sr 85 absorption by bone minerals in experiments in vitro Gigiena i Sanitariia 37(6): 40-43
Harada, K.; Murakami, T.; Kawasaki, E.; Higashi, Y.; Yamamoto, S.; Yata, N. 1993: In-vitro permeability to salicylic acid of human, rodent, and shed snake skin Journal of Pharmacy and Pharmacology 45(5): 414-418
Kahns, A.H.; Møss, J.; Bundgaard, H. 1992: Human skin permeability studies of desmopressin and some prodrug derivatives Acta Pharmaceutica Nordica 4(3): 187-188
Fullerton, A.; Christrup, L.; Bundgaard, H. 1991: Evaluation of the transdermal route for administration of narcotic analgesics: human skin permeability studies of methadone and pethidine Acta Pharmaceutica Nordica 3(3): 181-182
Aderounmu, A.F.; Salako, L.A. 1979: Plasma and erythrocyte cations and permeability of the erythrocyte membrane to cations in essential hypertension African Journal of Medicine and Medical Sciences 8(1-2): 45-49
Yancey, K.B. 1988: Biological properties of human C5a: selected in vitro and in vivo studies Clinical and Experimental Immunology 71(2): 207-210
Betz, E.; Heuser, D. 1978: Actions and interactions of cations and anions on pial arteries Advances in Neurology 20: 71-76
Baumbach, N.; Herzog, V.; Schiller, F. 1987: In vitro studies on the permeation of ethylene oxide through human skin Dermatologische Monatschrift 173(6): 328-332
Vogel, H.G. 1984: Biomechanical studies of human and animal skin in vivo and in vitro Zeitschrift für Hautkrankheiten 59(16): 1098-1100
Das, S.C.; Isichei, U.P.; Egbuta, J.O.; Banwo, A.I. 1989: Cations and anions in drinking water as putative contributory factors to endemic goitre in Plateau State, Nigeria Tropical and Geographical Medicine 41(4): 346-352
Okido, M.; Suzuki, K.; Sugihara, I.; Mizuno, N. 1974: Effects of ultraviolet irradiation on human skin lipids. in vivo and in vitro studies Acta Dermato-Venereologica 54(3): 223-226
Krishnaiah, Y.S.R.; Bhaskar, P.; Satyanarayana, V. 2004: In vitro percutaneous permeability enhancement of nimodipine by limonene across the excised rat abdominal skin Die Pharmazie 59(12): 942-947
Shvinka, N.E. 1974: Swelling of the T-system, caused by a constant current, as a characteristic of the movement of cations and anions through the T-system membranes Tsitologiia 16(8): 964-969
Vul', S.M.; Kolker, I.I. 1972: A comparative immunochemical analysis of the antigenic structure of burned human skin (burn scab) and thermically denatured (in vitro) human skin Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 16(3): 62-67
Lishko, V.K.; Saĭchenko, E.A.; Storchak, L.G.; Gimmerl'reĭkh, N.G. 1990: Latrotoxin channels. Permeability for divalent cations Biokhimiia 55(9): 1578-1583
Liberman, E.A.; Pronevich, L.A.; Topaly, V.P. 1970: Permeability mechanism of phospholipid membranes for cations in the presence of antibiotics Biofizika 15(4): 612-621
Slyn'ko, P.P.; Goncharuk, E.I.; Mil'ko, V.I.; Lazar', A.F. 1973: Specific permeability of human skin for aqueous solutions of chemical substances and its hygienic significance Gigiena i Sanitariia 38(11): 12-16
Ataullakhanov, R.I.; Ataullakhanov, F.I.; Abdullaev, D.M. 1984: Increase in the permeability of the lymphocyte plasma membrane for uni- and bivalent cations and low-molecular metabolites following exposure to mitogenic polyanions Biulleten' Eksperimental'noi Biologii i Meditsiny 98(7): 81-84
Kawamura, N.; Okada, K.; Kinoshita, H.; Sameshima, M.; Matsunaga, J.; Kawakami, T.; Hashimoto, T. 1987: Studies on the drug permeability of vesical walls. The permeability of mecillinam from the bladder Japanese Journal of Antibiotics 40(4): 739-742
Ludwicki, J.K. 1974: Effect of selected compounds on enzymes in lysosomal fractions of rat liver. I. in vitro studies Roczniki Panstwowego Zakladu Higieny 25(3): 287-293