Influence of parathyroid hormone and heparin on tooth development in mice homozygous for the microphthalmia mutation
Osipov, V.V.; Vakhrusheva, M.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 79(4): 110-112
1975
ISSN/ISBN: 0365-9615 PMID: 1191756 Document Number: 95130
In mice, homozygous by microphthalmia (mi/mi) gene the disturbance of dental development was due to defects in dental pulp and to the absence of bone resorpion. Administration of heparin or parathyroid hormone stimulated dental eruption in mi/mi mice. Following combined action of heparin and parathyroid hormone the number of erupted teeth was practically the same as after the action of heparin alone. Possibly the level of heparin is insufficient, but secretion of parathyroid hormone is unimpaired in mi/mi mice.