Canine osteosarcoma karyotypes from an original tumor, its metastasis, and tumor cells in tissue culture
Taylor, N.; Shifrine, M.; Wolf, H.G.; Trommershausen-Smith, A.
Transplantation Proceedings 7(4): 485-493
1975
ISSN/ISBN: 0041-1345 PMID: 1060210 Document Number: 94724
Radiation-induced osteosarcoma, its metastasis, and cells grown in tissue culture were karyotyped. Both hypodiploid and hyperdiploid stem lines were observed. The hypodiploid line contained 45-55 chromosomes with 10-15 abnormal metacentric and submetacentric chromosomes and one subtelocentric marker. The hyperdiploid line contained 90-105 chromosomes with 20-30 abnormal metacentric and submetacentric chromosomes with two subtelocentric markers. Karyotypic analysis can be used to monitor osteosarcomas maintained in tissue culture.