Training examiners to administer a quantitative neurological examination for a multicenter clinical trial
Henderson, W.G.; Tourtellotte, W.W.; Potvin, A.R.
Archives of Physical Medicine and Rehabilitation 56(7): 289-295
1975
ISSN/ISBN: 0003-9993 PMID: 167673 Document Number: 94661
A battery of quantitative neurological tests was used in a multicenter clinical trial to compare ACTH with placebo for the treatment of patients with multiple sclerosis in acute exacerbation. Since the battery of tests was administered in ten centers by physical therapists, it was critical that the examiners were well trained and remained so. Results of experiments showed that physical therapists could be successfully trained to administer the tests in a uniform fashion and remained trained for three years, the duration of the clinical trial. The fact that physical therapists are not taught tell-tale side effects of a treatment, and hence do not perceive these as do the physician examiners, introduces another level of objectivity into neurological clinical trials.