Study of the effect of the oxytetracycline crystallization conditions on the process indices
Lin'kov, G.I.; Zhukovskaia, S.A.
Antibiotiki 20(7): 591-595
1975
ISSN/ISBN: 0003-5637 PMID: 5049 Document Number: 94144
Such factors as the rate of the changes in pH, temperature, mixer speed and the nature of the anions present in the solution has a significant effect on the indices of oxytetracycline dihydrate crystallization, i. e. residual content of the antibiotic in the mother solution and the specific surface of the crystalls. In this connection the effect of the above factors on the main indices of the process were studied. On the basis of the experimental data dependences were found which provided determination of the crystallization conditions securing the process indices.