Drug-induced agranulocytosis. a survey of twenty-three episodes
Mintz, U.; Shaklai, M.; Pinkhas, J.; de Vries, A.
Medecine Interne 13(3): 205-208
1975
ISSN/ISBN: 0377-1202 PMID: 52883 Document Number: 93300
Twenty-three episodes of drug-induced agranulocytosis admitted to the Beilinson Medical Center between 1960-1972 are reported. An increased incidence in patients admitted with this condition was noted over the years. Dipyrone (6 episodes in 4 patients) and chloramphenicol (5 episodes in 5 patients) were the drugs most commonly associated with this condition. Four patients died in septic shock. The increased incidence of hospital-admitted patients with drug-induced agranulocytosis is related to the increased use of drugs in the Israeli population.