On the method of injecting into the yolk-sac in teratological studies in rabbits
Claussen, U.
Arzneimittel-Forschung 25(9): 1434-1436
1975
ISSN/ISBN: 0004-4172 PMID: 1242669 Document Number: 91454
A method is described by which the embryotoxic and teratogenic effects of substances can be examined through their application into the yolk-sac. On the ninth day of gestation rabbits (white New Zealand) were laparatomised and the uterus bicornis together with the blastoderms were treated in 3 different experiments. The results show that after application of physiological saline into the yolk-sac the high rate of malformations and resorptions are caused mainly by an avoidable venous obstruction and by postoperative inflammations and infections.
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