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The functional state of the adrenal cortex in patients with gonadal dysgenesis and a female phenotype

Genkova, P.; Kolarov, P.; Dokumov, S.; Spasov, S.; Stancheva, M.

Problemy Endokrinologii 21(1): 43-46

1975

ISSN/ISBN: 0375-9660
PMID: 166369
Document Number: 91322
Excretion of 17-KS and 17-OCS was studied in the urine of 86 patients with various cytogenetic variants of gonad dysgenesis of a female phenotype under basic conditions and after ACTH stimulation; in 10 patients endogenous hypophyseal ACTH reserve after block of the adrenal cortex by metopyrone was investigated as well. A conclusion was drawn on the presence in these patients of differnet types of deviations of the adrenal gland function. In some of the cases there is a primary "global" or dissociated injury of the adrenal cortex, apparently directly associated with gonosome anomaly; in other cases--with disturbed regulation of ACTH secretion.

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