Generalized pustular psoriasis following withdrawal of efalizumab
Gaylor, M.-L.N.; Duvic, M.
Journal of Drugs in Dermatology Jdd 3(1): 77-79
2004
ISSN/ISBN: 1545-9616 PMID: 14964752 Document Number: 9036
Efalizumab is one of the new biologic therapies targeting T-lymphocyte activity for the treatment of chronic plaque psoriasis. Common adverse effects include headaches, nonspecific infection, nausea, chills, and fever. Rebound of psoriasis following discontinuation of the drug has been reported. Relapse events can manifest as recurrent plaque psoriasis, guttate psoriasis, psoriatic erythroderma, and pustular psoriasis. We report a second case of withdrawal flare resulting in generalized pustular psoriasis.
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