Circulatory regulation in anuric rats: anuria and haemorrhagic hypotension
Debreczeni, L.A.; Albert, K.; Takács, L.
Acta Physiologica Academiae Scientiarum Hungaricae 46(2): 151-162
1975
ISSN/ISBN: 0001-6756 PMID: 1235232 Document Number: 89464
In rats made anuric by ureteral ligation or by creating a bladder-caval venous shunt, cardiac index increased and total peripheral resistance decreased proportionally to the change in the serum NPN level. Circulating blood and plasma volume did not change. In ureteral-ligated or bladder-caval venous-shunted rats, cardiac output and its organ fractions were determined by Sapirstein's technique. In the ureteral-ligated animals vasoconstriction in the kidneys and vasodilatation in the skin were found. After bladder-caval shunt vasodilatation developed in the myocardium, gut, skin and carcass. After ureteral ligation posthemorrhagic shifting decreased mainly the renal flow, while after a bladder-caval venous shunt, mainly the renal and intestinal flows.