Concentrations of trimethoprim and sulphadoxine in tissues from goats and a cow
Nielsen, P.; Rasmussen, F.
Acta Veterinaria Scandinavica 16(3): 405-410
1975
ISSN/ISBN: 0044-605X PMID: 1180195 Document Number: 89449
Concentration of trimethoprim and sulphadoxine in plasma and tissue from goats and a cow were determined after a single i/v injection. Furthermore, the concentrations of the two drugs and their metabolites in plasma and tissues were determined after continuous i/v infusion for 21/2-3 hours. Trimethoprim was present in all tissues but brain at higher concentrations than in plasma while the concentrations of sulphadoxine in the different tissues were lower than in plasma. The highest concentrations of the two drugs and their metabolites were found in kidney. The distribution pattern of trimethoprim and sulphadoxine was similar in cow and goat.