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Effect of nitrite on the phosphorolytic and hydrolytic glycogen decomposition in the heart and skeletal muscle

Dynarowicz, I.; Wilczek, J.; Garbuliński, T.

Polish Journal of Pharmacology and Pharmacy 27(5): 521-528

1975

ISSN/ISBN: 0301-0244
PMID: 241980
Document Number: 89216
Sodium nitrite produces indirectly an increase in glycogen phosphorolysis and hydrolysis both in the working heart muscle and in quiescent skeletal muscle. The results indicate this effect being related to catecholamines liberation as it never occurs after adrenalectomy, reserpine administration or beta-receptor blocking. The most significant effect of nitrite and adrenalin interaction consists in abolition of inhibiting influence of adrenalin upon glycogen hydrolysis which leads to significant increase in contribution of unphosphorylated sugars to the total pool of products liberated in a course of enhanced glycogenolysis process in the heart.

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