Blood-CSF kinetics of penicillin G in neurosyphilis
Ritter, G.; Volles, E.; Müller, F.; Nabert-Bock, G.
Münchener Medizinische Wochenschrift 117(35): 1383-1386
1975
ISSN/ISBN: 0341-3098 PMID: 809679 Document Number: 88844
Measurements of the penicillin concentration in serum and cerebrospinal fluid patients with neurosyphilis showed that conventional therapy can attain effective treponemocidal levels for only a short time or not at all in the CSF and brain-tissue, the regions where the treponemas are found in this particular stage of disease. Intravenous infusions with high doses (0,5 mega unit penicillin-G/kg body weight in 24 hours) over more than one generation phase of the treponemas (35-43 hours) considerably improve the recovery. 16 patients were treated in this way and been followed over 2-3 years clinically and immunologically.