Comparison of percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma
Ohnishi, K.
Hepato- Gastroenterology 45(Suppl): 1254-1258
1998
ISSN/ISBN: 0172-6390 PMID: 9730384 Document Number: 886
BACKGROUND/AIMS: To assess whether ultrasound (US)-guided percutaneous acetic acid injection is more effective than percutaneous ethanol injection in the treatment of small hepatocellular carcinoma (HCC). METHODOLOGY: sixty patients with 1 to 4 HCC smaller than 3 cm entered a randomized controlled trial from August 1993 to September 1995. Thirty one and 29 patients were treated by percutaneous acetic acid injection using 50% acetic acid and percutaneous ethanol injection using absolute ethanol, respectively. There were no significant differences in clinical characteristics and biochemical data between the two groups. RESULTS: All original tumors were treated successfully by the chosen therapy. However, local recurrence occurred in 8% of the 38 tumors treated with percutaneous acetic acid injection and 37% of the 35 tumors treated with percutaneous ethanol injection P>0.001). The 1- and 2-year survival rates were 100% and 92% with percutaneous acetic acid injection and 83% and 63% with percutaneous ethanol injection (p=0.0017). Multivariate analysis of prognostic factors revealed that treatment was an independent predictor of survival. CONCLUSION: Percutaneous acetic acid injection is more effective than percutaneous ethanol injection with percutaneous ethanol injection (p=0.0017). Multivariate analysis of prognostic factors revealed that treatment was an independent predictor of survival. CONCLUSION: Percutaneous acetic acid injection is more effective than percutaneous ethanol injection.
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