Effect of mexicor on oxidative stress in acute myocardial infarction
Golikov, A.P.; Davydov, B.V.; Rudnev, D.V.; Klychnikova, E.V.; Bykova, N.S.; Riabinin, V.A.; Polumiskov, V.I.; Nikolaeva, N.I.; Golikov, P.P.
Kardiologiia 45(7): 21-26
2005
ISSN/ISBN: 0022-9040 PMID: 16091656 Document Number: 8784
Mexicor (5% solution and capsules) was used in 40 of 80 conventionally treated patients with acute myocardial infarction. The drug was given intravenously for 5 days, than intramuscularly (6-9 mg/kg) for 9 days and orally (0.1 mg t.i.d.) thereafter until discharge. Severity of oxidative stress was evaluated by K coefficient. Calculation of this coefficient required data on degree of oxidation of lipids in blood serum, serum levels of diene conjugates, malonic dialdehyde, alpha-tocopherol and ceruloplasmin. These parameters as well as activity of superoxide dismutase, glutathione peroxidase and catalase in erythrocytes were measured at admission, on days 2, 3, 7, 14 and at discharge. Mexicor treated compared with untreated (n=40) patients were characterized by diminished severity of oxidative stress at the account of lower levels of lipid peroxidation products and augmented compensatory potential of the endogenous antioxidant system.
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