"Ground-glass" hepatocytes
Cohen, C.
South African Medical Journal 49(34): 1401-1403
1975
ISSN/ISBN: 0256-9574 PMID: 1162516 Document Number: 87753
"Ground-glass" hepatocytes are liver cells which have eosinophilic granular, glassy cytoplasm on light microscopy. This appearance corresponds to a proliferated smooth endoplasmic reticulum ultrastructure. These changes may be drug-induced or associated with hepatitis B antigenaemia, particularly in carriers. In the latter case, hepatitis B antigen may be demonstrated in the liver cell cytoplasm, with a modified orcein stain, by immunofluorescence, electron microscopy and immuno-electron microscopy. Two patients are described in whom "ground-glass" hepatocytes were noted on liver biopsy. One patient had been treated with high doses of phenobarbitone, the other is a hepatitis B antigen carrier as was demonstrated by the modified orcein stain.
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