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Investigation of some materials as dry binders for direct compression in tablet manufacture. Part 2: Comparative self-binding properties

Asker, A.F.; Saied, K.M.; Abdel-Khalek, M.M.

Die Pharmazie 30(4): 236-238

1975

ISSN/ISBN: 0031-7144
PMID: 1153489
Document Number: 87540
Comparative self-binding qualities of four substances studied as potential dry binders for direct compression applications in tablet making were investigated. The effect of particle size of these materials on hardness, friability and hardness-friability ratio of disks made with mere binders was studied. The results showed that for comparable particle sizes, values of hardness-friability ratio of the various disks were in the following descending order: Plasdone, tragacanth, Carbowax 4000 and then mannitol.

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