A therapeutic response to a single diagnostic dose of luteinising hormone-releasing hormone
Distiller, L.A.; Sagel, J.; Polakow, E.S.; Morley, J.E.
South African Medical Journal 49(2): 50-52
1975
ISSN/ISBN: 0256-9574 PMID: 1090013 Document Number: 87463
Luteinising hormone-releasing hormone (LH-RH) administration is a useful provocative test for the evaluation of the hypothalamic-pituitary-gonadal axis. Seven cases with oligomenorrhoea or amenorrhoea are reported, in which a single diagnostic injection of LH-RH produced an apparent therapeutic response. Six patients converted to a regular normal menstrual cycle, and 4 of these had evidence of ovulation. The seventh patient conceived. It is postulated that in some cases of hypothalamic menstrual dysfunction the gonadotrophic imbalance may be corrected by a single intravenous dose of LH-RH.