Disaccharidases of Intestinal Mucosa in a Patient with Sucrose Intolerance
Launiala, K.; Perheentupa, J.; Visakorpi, J.; Hallman, N.
Pediatrics 34: 615-620
1964
ISSN/ISBN: 0031-4005 PMID: 14227640 Document Number: 8725
A thorough clinical and enzymological study is reported in a patient suffering from typical sucrose intolerance. In addition to sucrose intolerance, a subclinical intolerance of maltose was demonstrated. Enzyme assay in a specimen of duodenal mucosa obtained by peroral tube biopsy revealed decreased activities of isomaltase, sucrase, and maltase. The assay was repeated following a three-month period on a sucrose-free diet with identical results. In the light of these findings the present information on intestinal α-glucosidases is discussed. The authors suggest that sucrose intolerance is due to a defect of one mucosal enzyme, the various α-glucosidase activities of which are differently affected by heat.
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