Autoimmunity as possible evoking factor of some so-called idiopathic bone marrow hypoplasias

Chudomel, V.; Novák, J.T.; Pekárek, J.; Svejcar, J.; Láznicka, M.; Chudomel, V; Novák, J.T; Pekárek, J; Svejcar, J; Láznicka, M

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Autoimmunity as possible evoking factor of some so-called idiopathic bone marrow hypoplasias

Chudomel, V.; Novák, J.T.; Pekárek, J.; Svejcar, J.; Láznicka, M.

Zeitschrift für Immunitatsforschung Experimentelle und Klinische Immunologie 150(5): 379-383

1975

ISSN/ISBN: 0300-872X

PMID: 133542

Document Number: 87019

Patients with bone marrow hypoplasia or aplasia were examined using the method of lymphocyte blast transformation and the MIF production test. The experimental results demonstrated the presence of an autoimmune process in these patients. A good congruence of the methods was demonstrated. Possible role of the autoimmune process in the pathogenesis of the disease as well as the reasons for the autoimmunity development and the therapeutical implications of these findings are discussed.