Diazoxide test in the diagnosis of arterial hypertension: modifications in the levels of renin and aldosterone in blood of patients with various restrains of the renal function
Cecchettin, M.; Albertini, A.; Ghielmi, S.; Signorini, C.; Orlandini, A.; Maiorca, R.
Quaderni Sclavo di Diagnostica Clinica E di Laboratorio 11(2): 397-406
1975
ISSN/ISBN: 0033-4979 PMID: 1223945 Document Number: 86818
The AA. have applied the diazoxide test for the screening of primary hiperaldosteronism to 22 nephropatic patients suffering from hypertension and with different degrees of renal function. In 22 patients an increase in PRA and aldosterone values always followed the diazoxide infusion. Only one patient, likely suffering from primary aldosteronism, showed no increase in PRA and aldosterone values. The diazoxide infusion had no influence on renal, pancreatic and cardiovascular function. Therefore, this can be considered as a valid test easy to be performed in a short time, also in nephropatic patients who are very sensitive to pharmacological noxae.