Effect of the stereoisomers of glutamic acid on the vital activity of auxotrophic mutant producers of lysine
Marshavina, Z.V.; Makarova, E.N.; Mkhitarian, A.R.; Nikogoscova, N.R.
Prikladnaia Biokhimiia i Mikrobiologiia 11(5): 669-672
1975
ISSN/ISBN: 0555-1099 PMID: 1187569 Document Number: 86756
Studies of L, D and DL-forms of glutamic acid as the sole nitrogen source or as a supplement to the major nitrogen source--ammonium sulphate have demonstrated that in the first case all forms of glutamic acid are assimilated by auxotrophic mutants--lysine producers. However, the lysine synthesis was very low, when L-glutamic acid was used as the only nitrogen source. Glutamic acid at a concentration of 0.01 M applied as a supplement to the major source of nitrogen acted as a stimulator of lysine synthesis, slightly inhibiting biomass increment. That was true of every form of glutamic acid, especially of DL-glutamic acid.