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Cushing's syndrome associated with a bronchial adenoma. Possible periodic hormonogenesis

Shapiro, M.S.; Gutman, A.; Bruderman, I.; Myers, B.; Griffel, W.B.

Israel Journal of Medical Sciences 11(9): 919-924

1975

ISSN/ISBN: 0021-2180
PMID: 1184365
Document Number: 85802
Diagnostic and therapeutic problems in a patient with ectopic ACTH syndrome caused by a malignant bronchial adenoma are discussed. Persistent Cushing's syndrome was present following apparent total adrenalectomy, but radioactive scanning with 131I-19-iodocholesterol showed the presence of residual adrenal tissue in the right suprarenal bed. Amelioration of the hypercortisolism occurred after removal of the bronchial adenoma. A paradoxical elevation of adrenocortical activity followed administration of dexamethasone and data are presented which suggest that periodic secretion of ACTH accounted for this phenomenon.

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