Technetium polyphosphate and technetium diphosphonate. a comparative study
Henne, W.; Pixberg, H.U.; Pfannenstiel, P.
Nuclear-Medizin 14(2): 83-90
1975
ISSN/ISBN: 0029-5566 PMID: 1178518 Document Number: 85090
99mTc-labelled phosphates are the bone seeking agents of choice. The comparison of 99mTc-polyphosphate (Poly-P) and 99mTc-ethane-1-hydroxy-1,1-diphosphonate (EHDP) shows a better in vitro stability of the latter during the first two hours after preparation. The blood clearance of EHDP is superior to Poly-P resulting in reduced background activity at scanning time. Renal excretion over a 4-hour period of urine sampling showed no significant differences between both substances. Blood activity is independent of diuresis.