Sarcomatous and leukemic forms of Waldenström's macroglobulinemia
Dao, C.; Zittoun, R.; Diebold, J.; Cadiou, M.; Reynes, M.; Gaudric, M.; Tricot, G.; Bousser, J.
La Semaine des Hopitaux Organe Fonde Par l'Association d'Enseignement Medical des Hopitaux de Paris 51(48): 2935-2942
1975
ISSN/ISBN: 0037-1777 PMID: 175505 Document Number: 84914
Four cases of sarcomatous or leukaemic types of Waldenström's macroglobulinemia are presented. They are characterized by tumoral and compressive localizations of lymph node or spleen, or by a hyper-leukocytosis with many circulating abnormal cells. These cells are different from the lympho-plasma cells regularly observed in Waldenström's macroglobulinemia, and can be assimilated to malignant immunoblasts. They have a proliferative aspect and seem to produce less macroglobulin and to recover some beta-glucuronidase activity. The sarcomatous and leukemic types of Waldenström's macroglobullinemia have a poor prognosis and may appear as terminal transformation of the disease.