Autologous stem cell transplantation in addition to cardiomyoplasty in a porcine model of ischemic cardiomyopathy
Poncelet, A.; Gianello, P.
Bulletin et Memoires de l'Academie Royale de Medecine de Belgique 158(5-6): 315-320
2003
ISSN/ISBN: 0377-8231 PMID: 15025273 Document Number: 8341
Autologuous stem cell transplantation within regional infarcted or ischemic myocardium is currently a focus of experimental research world-wide, and could provide a unique way to ensure myocardial functional recovery. In order to benefit from immediate access to bone marrow stromal cells at the time of myocardial injury, and thus avoid the delay rendered necessary by autologuous harvesting and clonal expansion, the use of allogeneic stem cell could be of major interest. This experimental work is based on a unique mini-swine model in which the histocompatibility antigens are known, and perfectly controlled, through inbreeding and investigate the survival and the induction of an immune tolerance to allogeneic stem cells injected into the infarcted myocardium with the use of transient immunosuppression (12 days).
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