Surface properties of T- and B-cells in leukaemic AKR mice
Phondke, G.P.; Sundaresan, P.; Singh, B.; Sundaram, K.
Indian Journal of Cancer 12(4): 405-415
1975
ISSN/ISBN: 0019-509X PMID: 1082848 Document Number: 83347
Electrophoretic mobilities (EPM) at T [thymus-derived]- and B [bone marrow-derived]-cells of normal and leukemic AKR mice were measured before and after treatment with neuraminidase and various specific antisera. T-cells possess a higher surface concentration of sialic acid residues than B-cells; but this situation is reversed on malignant development. .THETA.-Isoantigen, present only on the surface of T-cells, disappears on leukemic development. There is considerable depletion in the concentration of surface immunoglobulin of B-cells. Concomitant with the loss of these surface antigens the leukemic cells appear to have gained some tumor-specific histocompatibility antigens. Similar studies were also done with normal and leukemic thymocytes. The surface sialic acid concentration of thymocytes is different from that of T- or B-cells and is reduced as a result of malignancy. .THETA.-Isoantigen present on normal cells cannot be detected in the case of leukemic cells. Immunoglobulins are absent from the surface of normal and leukemic cells. The tumor-specific histocompatibility antigens also appear to have emerged on the surface of leukemic thymocytes.