Arsobal in the treatment of Rhodesian sleeping-sickness
Silva, M.A.; Caseiro, A.; Carmo, R.P.; De Basto, A.X.
Anais do Instituto de Medicina Tropical 11(2): 261-285
1954
ISSN/ISBN: 0365-3307 PMID: 13314057 Document Number: 8318
We have described above the results obtained with arsobal. Three groups with a total of 165 cases were treated. All patients were in hospital during treatment this being the procedure in Mozambique. The dosage arsobal in all cases was one of 3,6 mgrs. per kgr. of body weight. The number and the sequence of the injections varied sometimes for the sake of experimenting with the drug, other times according to the condition of the patients. Nearly all cases were followed up for an average period of 6 to 14 months. According to our findings arsobal is of definite value in the treatment of T. rhodesiense sleeping sickness in the nervous stage, even in those cases where previous use of tryparsamide had failed. We have mentioned the fatal accidents following the arsobal treatment. Only one early case was treated. The patient got cured. We think that arsobal is too dangerous to be used in the early stage of the disease since antrypol and pentamidine (isethionate) easily cure these cases.
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