Effects of anti-Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS, by specific anti-Ia sera

Niederhuber, J.E.; Frelinger, J.A.; Dugan, E.; Coutinho, A.; Shreffler, D.C.; Niederhuber, J.E; Frelinger, J.A; Dugan, E; Coutinho, A; Shreffler, D.C

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Effects of anti-Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS, by specific anti-Ia sera

Niederhuber, J.E.; Frelinger, J.A.; Dugan, E.; Coutinho, A.; Shreffler, D.C.

Journal of Immunology 115(6): 1672-1676

1975

ISSN/ISBN: 0022-1767

PMID: 1081105

Document Number: 83071

Specific anti-Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti-Ia antibodies, but not with specific anti-H-2K antibodies. The population of splenic B cells resistant to anti-Thy-1.2 serum and complement was blocked in a very similar manner by anti-Ia serum, but not by anti-H-2 serum.