Matrical inclusions induced by clofibrate in hepatic microbodies of rats fed 2-acetylaminofluorene
Tsukada, H.; Mochizuki, Y.; Gotoh, M.
Journal of the National Cancer Institute 54(2): 519-523
1975
ISSN/ISBN: 0027-8874 PMID: 1113332 Document Number: 83041
Abnormal inclusions in microbodies were induced by clofibrate in hepatocytes of hyperplastic liver nodules in rats fed 2-acetylaminofluorene. These were matrical tubules and plates, each with the same ultrastructural features as those reported previously by other investigators. A hyperplastic state of hepatocytes induced by hepatocarcinogens might be related to the formation of these inclusions in response to clofibrate.
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