Acute nonlymphoblastic leukemia as a secondary malignancy--demonstration of 15 patients
Płuzańska, A.; Krykowski, E.; Urbańska-Ryś, H.; Polkowska-Kulesza, E.; Gołebiowska, A.; Dowgier-Witczak, I.
Acta Haematologica Polonica 23(4): 271-275
1992
ISSN/ISBN: 0001-5814 PMID: 1293909 Document Number: 816
Among 90,128 patients with malignancies in the years 1976 - 1989 acute non lymphoblastic leukaemia (ANLL) was diagnosed in 351 patients (0.4%) and in 15 (4.3%) of them ANLL was secondary neoplasm. Secondary ANLL occurred in 10% of all the 148 secondary malignancies observed at that period of time and constituted 6.7% of secondary malignancy in patients with solid tumors and 43% in patients with myeloproliferative syndromes as a first malignant neoplasm. In the treatment of first malignancy radiotherapy was applied in 11 persons, in combination with chemotherapy in 7 of them and chemotherapy alone was given to 4 patients. The appearance of the secondary ANLL was usually preceded by the myelodysplastic syndrome. Morphologically, secondary ANLL belonged mostly to M-6 and M-4 (8 patients) according to FAB classification. The course of ANLL was fulminant and the disease was completely resistant to the treatment.
Document emailed within 1 workday
