The rat mast cell degranulation assay as an in vitro allergy test
Wetherall, J.D.; Hackshaw, R.; Turner, K.J.
Australian and New Zealand Journal of Medicine 4(2): 187-191
1974
ISSN/ISBN: 0004-8291 PMID: 4137996 Document Number: 81180
Rat mast cell degranulation has been utilised to detect human reagins to the drugs penicillin, insulin, rifampicin, cycloserine and lignacaine and to rheomacrodex. The specificity of the method for human Ig E was established by the induction of degranulation with anti-Ig E. The technique appears to have limitations as a potential tool for routine clinical diagnosis.
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