Episodic dyscontrol: a controlled replication
Maletzky, B.M.; Klotter, J.
Diseases of the Nervous System 35(4): 175-179
1974
ISSN/ISBN: 0012-3714 PMID: 17894113 Document Number: 78979
The authors describe previous research in which the syndrome of episodic dyscontrol is delineated and a majority of patients treated successfully with diphenyldantoin (Dilantin). This original research was uncontrolled because of an ethical dilemma: to withhold active treatment for violent outbursts might result in damage to people or property. The present study undertakes a controlled replication of this original research employing sequential analysis in a double blind discontinuation trial such that no patient was denied active treatment any longer than absolutely necessary. Results indicate a clear superiority for Dilantin over placebo when both were added to a psychotherapeutic treatment regimen for violent behavior. Conclusions based on these results are discussed and suggestions for future research offered.