Strychnine-insensitive glycine/NMDA sites are altered in two stress models of depression
Nowak, G.; Ossowska, G.; Jopek, R.; Papp, M.
Polish Journal of Pharmacology 50(4-5): 365-369
1998
ISSN/ISBN: 1230-6002 PMID: 10091723 Document Number: 7684
Chronic severe stress (CSS) and chronic mild stress (CMS) affect the properties of [3H]5,7-dichlorokynurenic acid (5,7-DCKA) binding to strychnine-insensitive glycine/NMDA sites in the rat cerebral cortex. Specifically, CSS decreases, while CMS increases, the potency of glycine to displace [3H]5,7-DCKA binding to glycine/NMDA sites. Moreover, in both models, a reduction of the specific [3H]5,7-DCKA binding was observed. The present results demonstrate the involvement of the cortical NMDA receptor complex in the animal models of depression.
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