Depletion of B lymphocytes in chronic hypoplastic marrow failure (aplastic anaemia)
Morley, A.; Holmes, K.; Forbes, I.
Australian and New Zealand Journal of Medicine 4(6): 538-541
1974
ISSN/ISBN: 0004-8291 PMID: 4549552 Document Number: 75137
The numbers of B and T lymphocytes were measured in nine patients with chronic hypoplastic mar-row failure and significant depletion of B but not of T lymphocytes was found. The lesion in the disease therefore appears to affect lymphopoiesis in addition to myelopoiesis. Study of surface immunoglobulin markers in three patients provided no evidence of clonal nature of the lymphocytes in the disease.
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